Psilocybin Therapy in Colorado

Colorado is one of the only places in the United States where adults can legally access psilocybin-assisted therapy outside of a clinical trial. The Natural Medicine Health Act (Proposition 122), passed by voters in 2022 and fully operational statewide, created a regulated framework of licensed facilitators, approved healing centers, and rigorous training requirements — making Colorado a national leader in the emerging field of regulated psychedelic therapy.

Why Colorado Matters

The clinical evidence for psilocybin-assisted therapy has been building for more than two decades at institutions like Johns Hopkins, NYU, and Imperial College London. Meta-analyses now show large effect sizes for treatment-resistant depression, durable reductions in cancer-related anxiety, and meaningful outcomes for PTSD, end-of-life distress, and personal growth. What Colorado added is access: a legal pathway for adults 21 and older to work with trained, licensed professionals without waiting for FDA approval or traveling abroad.

How the Colorado Program Works

Under the Natural Medicine Health Act, psilocybin is not sold over the counter and it is not legally prescribed. Instead, the program operates on a facilitator-centered model: adults 21+ work with a licensed natural medicine facilitator who has completed over 100 hours of specialized training, and psilocybin is administered in a regulated setting at a licensed natural healing center. A full therapeutic arc includes preparation, the psilocybin session itself, and integration — the three phases supported by decades of clinical research.

Read our full guide to Colorado's Natural Medicine Health Act →

What Psilocybin Therapy Addresses

Psilocybin-assisted therapy has clinical evidence — and is pursued by Colorado residents — for a range of conditions and contexts:

Where We Serve

Peak Psychedelic Wellness is based at 5300 DTC Parkway in Greenwood Village — near the Denver Tech Center in the heart of the south Denver metro. From that base, we regularly serve clients across Colorado's Front Range:

Retreat vs. Facilitator-Led Therapy

Much of the early press around Colorado's program has focused on "psilocybin retreats" — multi-day, often group-based experiences at destination locations. Retreats can be meaningful, but they are only one mode of access within the law. A facilitator-led therapeutic arc — preparation sessions with your facilitator over a period of weeks, an individual or small-group administration session at a licensed healing center, followed by several weeks of integration work — provides a different kind of container: continuity of relationship, individualized pacing, and therapy-grade integration support. Retreats vs. facilitator-led therapy: a comparison →

Frequently Asked Questions